期刊
CHEMSUSCHEM
卷 10, 期 12, 页码 2685-2691出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201700491
关键词
biphasic; catalyst recycling; downstream processing; organocatalysis; switchable catalysts
资金
- DFG [KR 2491/12-1]
CO2-induced switchable tertiary amine-based organocatalysts were investigated for an efficient catalyst and product separation by its different partitioning between an organic and carbonated water phase. In this case study, the switching ability of eight tertiary amine-based catalysts between the organic and water phase by addition or removal of CO2 was investigated. Here, the catalyst switched both nearly completely (99.9%) into the aqueous phase by addition of CO2 and effectively back into the organic phase (99.3 %) by expelling CO2. With this technique, the organocatalyst was successfully recovered and reused twelve times without significant loss of activity (up to 90% enantiomeric excess) for the asymmetric nitroaldol (Henry) reaction. After the first catalyst switch, evaporation of the solvent affords the product in 98% purity without any further purification steps.
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