期刊
CLINICAL IMMUNOLOGY
卷 180, 期 -, 页码 5-10出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2017.03.013
关键词
E4BP4; Mouse models; Cellular processes; Immune-mediated-diseases
类别
资金
- National Natural Science Foundation of China [81220108017, 81430074, 81301357, 30972745]
- National Institutes of Health [R01 AI090901, AI121196, AI123253]
- Research Fund for Postgraduate Innovation Project of Central South University [2015zzts309]
Basic leucine zipper transcription factor E4BP4 (also known as NFIL3) has been implicated in the molecular and cellular mechanisms of functions and activities in mammals. The interactions between E4BP4 and major regulators of cellular processes have triggered significant interest in the roles of E4BP4 in the pathogenesis of certain chronic diseases. Indeed, novel discoveries have been emerging to illustrate the involvement of E4BP4 in multiple disorders. It is recognized that E4BP4 is extensively involved in some immune-mediated diseases, but the mechanisms of E4BP4 involvement in these complex diseases remain poorly defined. Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies. (C) 2017 Published by Elsevier Inc.
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