期刊
BEHAVIOURAL BRAIN RESEARCH
卷 328, 期 -, 页码 48-56出版社
ELSEVIER
DOI: 10.1016/j.bbr.2017.03.014
关键词
BDNF; rs6265; Neurogenetics; sMRI neuroimaging; Gray matter volume; Cortical thickness; Surface area; Development
资金
- NIH [R01 HD 048830, P01 HD052120, P01 HD 001994, R03 HD053409]
The brain-derived neurotrophic factor (BDNF) Val(66)Met single nucleotide polymorphism (SNP) has been associated with individual differences in brain structure and function, and cognition. Research on BDNF's influence on brain and cognition has largely been limited to adults, and little is known about the association of this gene, and specifically the Val(66)Met polymorphism, with developing brain structure and emerging cognitive functions in children. We performed a targeted genetic association analysis on cortical thickness, surface area, and subcortical volume in 78 children (ages 6-10) who were Val homozygotes (homozygous Val/Val carriers) or Met carriers (Val/Met, Met/Met) for the Val(66)Met locus using Atlas-based brain segmentation. We observed greater cortical thickness for Val homozygotes in regions supporting declarative memory systems (anterior temporal pole/entorhinal cortex), consistent with adult findings. Met carriers had greater surface area in the prefrontal and parietal cortices and greater cortical thickness in lateral occipital/parietal cortex in contrast to prior adult findings that may relate to performance on cognitive tasks supported by these regions in Met carriers. Finally, we found larger right hippocampal volume in Met carriers, although inconsistent with adult findings (generally reports larger volumes for Val homozygotes), is consistent with a recent finding in children. Gene expression levels vary across different brain regions and across development and our findings highlight the need to consider this developmental change in explorations ofBDNF-brain relationships. The impact of the BDNF Val(66)Met polymorphism on the structure of the developing brain therefore reflects regionally-specific developmental changes in BDNF expression and cortical maturation trajectories. (C) 2017 Elsevier B.V. All rights reserved.
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