期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 45, 期 -, 页码 665-681出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20160331
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资金
- Australian Government Research Training Program Scholarship
- National Health and Medical Research Council of Australia (NHMRC) fellowship [1105754]
- NHMRC Project grants [1057905, 1067289, 1124735, 1124737]
- NHMRC IRIISS [9000220]
- Victorian Government Operational Infrastructure
- National Health and Medical Research Council of Australia [1067289, 1057905, 1124735, 1124737] Funding Source: NHMRC
Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise similar to 10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies. Pseudokinases are the catalytically defective counterparts of conventional, active protein kinases and have been attributed functions as protein interaction domains acting variously as allosteric modulators of conventional protein kinases and other enzymes, as regulators of protein trafficking or localisation, as hubs to nucleate assembly of signalling complexes, and as transmembrane effectors of such functions. Here, by categorising mammalian pseudokinases based on their known functions, we illustrate the mechanistic diversity among these proteins, which can be viewed as a window into understanding the non-catalytic functions that can be exerted by conventional protein kinases.
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