期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 26, 页码 21673-21687出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b05278
关键词
Dacarbazine; hollow mesoporous silica nanoparticles; folic acid; melanoma; target delivery
资金
- National Natural Science Foundation of China [51473059, 81301364]
- Natural Science Foundation of Hubei Scientific Committee [2015BHE001]
- Shenzhen Science and Technology Project [JCYJ20150630155150194]
Dacarbazine (DTIC) is one of the most important chemotherapeutic agents for the treatment of melanoma; however, its poor solubility, photosensitivity, instability; and serious toxicity to normal cells limit its clinical applications. In this article, we present a rationally designed nanocarrier based on hollow mesoporous silica nanoparticles (HMSNs) for the encapsulation and targeted release of DTIC for eradicating melanoma. The nanocarrier (DTIC@HMLBFs) is prepared by modifying. HMSNs with carboxyl groups to enhance the loadingd of DTIC, followed by further enveloping of folic acid-grafted liposomes, which act as a melanoma active target for controlled and targeted drug release. In vitro, DTIC@HMLBFs exhibited the strongest cytotoxicity to melanoma cells compared with DTIC@HMSNs and free DTIC. The in vivo investigations demonstrate that the rationally designed nanocarrier loaded with DTIC achieves significant improvement against lung metastasis of melanoma via targeting melanoma cells and tumor-associated' macrophages. This study provides a promising platform for the design and fabrication of multifunctional nanomedicines, which are potentially useful for the treatment of melanoma.
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