期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 2, 页码 291-299出版社
WILEY
DOI: 10.1002/eji.201545886
关键词
Amino acid IL-17 mTORC1 STAT HIF-1
类别
资金
- National Key Basic Research Program of China [2013CB127302, 2013CB127301]
- National Natural Science Foundation of China [31330075, 31372326, 31110103909, 31272463]
- Texas A&M AgriLife Research [H-8200]
IL-17 mediates immune responses against extracellular pathogens, and it is associated with the development and pathogenesis of various autoimmune diseases. The expression of IL-17 is regulated by various intracellular signaling cascades. Recently, it has been shown that mechanistic target of rapamycin (mTOR) signaling, comprised mainly of mTORC1 signaling, plays a critical role in IL-17 expression. Here, we review the current knowledge regarding mechanisms by which mTORC1 regulates IL-17 expression. mTORC1 positively modulates IL-17 expression through several pathways, i.e. STAT3, -HIF-1, -S6K1, and -S6K2. Amino acids (AAs) also regulate IL-17 expression by being the energy source for Th17 cells, and by activating mTORC1 signaling. Altogether, the AA-mTORC1-IL-17 axis has broad therapeutic implications for IL-17-associated diseases, such as EAE, allergies, and colitis.
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