期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 3, 页码 732-741出版社
WILEY
DOI: 10.1002/eji.201546081
关键词
B cell; B-1 B cells; Class switch(ing); NF-kappa B-inducing kinase (NIK)
类别
资金
- DFG [HO 4440/1-1/2, SFB/TRR TR156, AW 1600/8-1]
- Research Center Immunology (FZI)
NF-kappa B-inducing kinase (NIK) is a key mediator of the noncanonical NF-kappa B signaling pathway, which is critical for normal B-cell development and function. It is well established that the complete deletion of NIK in mice results in defective B cells and impaired secondary lymphoid organogenesis. To address the role of NIK deficiency specifically in B cells, we generated a new mouse strain for the conditional deletion of this kinase. Deletion of NIK during B-cell development results in a drastic reduction of mature B cells from the transitional 2 stage on, while B-1 B cells are less affected. Moreover, deletion of NIK in the germinal centers decreases the numbers of germinal center B cells and impairs the ability of NIK-deficient B cells to develop into class-switched cells in vivo. This new mouse strain will be helpful for studying the role of NIK in different cell types of the body.
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