期刊
BIOESSAYS
卷 39, 期 7, 页码 -出版社
WILEY
DOI: 10.1002/bies.201700001
关键词
cell death; cell size; heterogeneity; metabolic scaling; mitochondria; mitochondrial membrane potential
资金
- Biotechnology and Biological Sciences Research Council [1376934] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/N014529/1] Funding Source: researchfish
- Medical Research Council [MR/J013617/1] Funding Source: researchfish
- Medical Research Council [MR/J013617/1] Funding Source: Medline
- EPSRC [EP/N014529/1] Funding Source: UKRI
- MRC [MR/J013617/1] Funding Source: UKRI
Heterogeneity in mitochondrial content has been previously suggested as a major contributor to cellular noise, with multiple studies indicating its direct involvement in biomedically important cellular phenomena. A recently published dataset explored the connection between mitochondrial functionality and cell physiology, where a non-linearity between mitochondrial functionality and cell size was found. Using mathematical models, we suggest that a combination of metabolic scaling and a simple model of cell death may account for these observations. However, our findings also suggest the existence of alternative competing hypotheses, such as a non-linearity between cell death and cell size. While we find that the proposed non-linear coupling between mitochondrial functionality and cell size provides a compelling alternative to previous attempts to link mitochondrial heterogeneity and cell physiology, we emphasise the need to account for alternative causal variables, including cell cycle, size, mitochondrial density and death, in future studies of mitochondrial physiology.
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