期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 101, 期 1, 页码 5-22出版社
CELL PRESS
DOI: 10.1016/j.ajhg.2017.06.005
关键词
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资金
- Australian National Health and Medical Research Council [1107258, 1078901, 1078037, 1056929, 1048853, 1113400]
- gs2:Sylvia and Charles Viertel Charitable Foundation
- NIH [GM099568, MH100141-01, MH095034, MH109897, DK098032, DK085545, MH101814, DKD105535]
- Wellcome Trust [090532, 090367, 098381, 106130]
- UK Medical Research Council [L020149, 004422, J010642]
- Innovative Medicines Initiative
- Accelerating Medicines Partnership (via the Foundation for the NIH)
- National Health and Medical Research Council of Australia [1056929] Funding Source: NHMRC
- Medical Research Council [MR/J010642/1, MR/L020149/1, MR/M004422/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10099] Funding Source: researchfish
- MRC [MR/L020149/1, MR/M004422/1, MR/J010642/1] Funding Source: UKRI
Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.
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