期刊
AUTOPHAGY
卷 13, 期 6, 页码 1084-1085出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2017.1307486
关键词
ferritin; galectins; inflammasome; IL1B; SNAREs; TRIMs; unconventional secretion
类别
资金
- NIAID NIH HHS [R37 AI042999] Funding Source: Medline
Macroautophagy/autophagy plays a role in unconventional secretion of leaderless cytosolic proteins. Whether and how secretory autophagy diverges from conventional degradative autophagy is unclear. We have shown that the prototypical secretory autophagy cargo IL1B/IL-1 beta (interleukin 1 beta) is recognized by TRIM16, and that this first to be identified secretory autophagy receptor interacts with the R-SNARE SEC22B to jointly deliver cargo to the MAP1LC3B-II-positive sequestration membranes. Cargo secretion is unaffected by knockdowns of STX17, a SNARE catalyzing autophagosome-lysosome fusion as a prelude to cargo degradation. Instead, SEC22B in combination with plasma membrane syntaxins completes cargo secretion. Thus, secretory autophagy diverges from degradative autophagy by using specialized receptors and a dedicated SNARE machinery to bypass fusion with lysosomes.
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