期刊
CHEMCATCHEM
卷 9, 期 13, 页码 2480-2487出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201700063
关键词
biocatalysis; biotransformations; enantioselectivity; enzymes; reduction
The reduction of (Z)-beta-acylaminonitroalkenes catalyzed by enereductases is described for the first time. The reaction occurs with a high conversion and excellent enantioselectivity and shows a wide substrate scope. The reduced products are valuable chiral synthons characterized by two vicinal nitrogen-containing functional groups that can be further modified by functional group inter-conversion thanks to the synthetic versatility of the nitro moiety. The chemo-enzymatic synthesis of (R)-N, N'-(1-phenylethane-1,2-diyl)diacetamide from easily accessible (Z)-N-(2-nitro-1-phenylvinyl)acetamide is herein reported as a representative application of this synthetic procedure.
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