期刊
NEUROPSYCHIATRIC DISEASE AND TREATMENT
卷 13, 期 -, 页码 1661-1667出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S140634
关键词
microglia; multiple sclerosis; macrophage; myelin
资金
- Innovation Project of Guangxi Graduate Education
- Guangxi Natural Science Foundation [2016GXNSFCA380012]
- Ability Enhancement Program for Young and Middle-age Teachers of Guangxi [2017KY056]
- Clinical Key Disciplines Construction Projects of Guangxi Zhuang Autonomous Region
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. In the past, microglia were considered to be the same cell type as macrophages, and researchers have different opinions about the role of microglia in MS. This review focuses on the original classification of microglia and their role in the pathogenesis of MS. Moreover, we present a hypothetical model for the role of microglia in the pathogenesis of MS based on recent findings.
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