期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 15, 页码 2749-2760出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2526-9
关键词
S100A6 protein; Proliferation; Migration/motility; Cancer; Invasion; Cytoskeleton; Receptor
资金
- Associazione Italiana Ricerca sul Cancro [17581]
S100A6 protein belongs to the A group of the S100 protein family of Ca2+-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin beta 1 transduce some extracellular S100A6's effects. Dosage of serum S100A6 might aid in diagnosis in oncology.
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