期刊
PHYSIOLOGICAL RESEARCH
卷 66, 期 2, 页码 219-233出版社
ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
DOI: 10.33549/physiolres.933407
关键词
Exercise intensity; Hypertension; BKCa channel
类别
资金
- National Natural Science Foundation of China [31371201]
- Chinese Universities Scientific Fund [2015ZD008, 2016RC001]
- General Administration of Sport of China [2015B035]
- Beijing Natural Science Foundation [5172023]
Accumulating evidence indicates that hypertension is associated with ion channel remodeling of vascular smooth muscle cells (VSMCs). The objective of this study was to determine the effects of exercise intensity/volume on hypertension-associated changes in large-conductance Ca2+-activated K+ (BKCa) channels in mesenteric arteries (MAs) from spontaneously hypertensive rats (SHR). Male SHRs were randomly assigned to three groups: a low-intensity aerobic exercise group (SHR-L: 14 m/min), a moderate-intensity aerobic exercise group (SHR-M: 20 m/min), and a sedentary group (SHR). Age-matched Wistar-Kyoto rats (WKYs) were used as normotensive controls. Exercise groups completed an 8-week exercise program. Elevation of the a and beta 1 proteins was unequal in MA myocytes from SHRs, with the beta 1 subunit increasing more than the a subunit. BKCa contribution to vascular tone regulation was higher in the myocytes and arteries of SHRs compared to WKYs. SHR BKCa channel subunit protein expression, beta 1/a ratio, whole cell current density and single-channel open probability was also increased compared with WKYs. Aerobic exercise lowered systemic blood pressure and normalized hypertension-associated BKCa alterations to normotensive control levels in the SHRs. These effects were more pronounced in the moderate-intensity group than in the low-intensity group. There is a dose-effect for aerobic exercise training in the range of low to moderate-intensity and accompanying volume for the correction of the pathological adaptation of BKCa channels in myocytes of MAs from SHR.
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