期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 29, 页码 8446-8450出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701550
关键词
adjuvants; antitumor activity; immunotherapy; multi-shelled materials; organosilica
资金
- Australian Research Council
- Queensland Government
Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.
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