期刊
CURRENT PROBLEMS IN CANCER
卷 41, 期 3, 页码 194-200出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.currproblcancer.2017.01.002
关键词
Genomic profiling; Adolescent and young adult cancer; Pediatric tumors; Whole-exome sequencing; RNA sequencing; Next-generation sequencing
类别
资金
- National Cancer Institute (NCI) [1U10CA180886]
With the use of high-throughput molecular profiling technologies, precision medicine trials are ongoing for adults with cancer. Similarly, there is an interest in how these techniques can be applied to tumors in children and adolescents to expand our understanding of the biology of pediatric cancers and evaluate the clinical implications of genomic testing for these patients. This article reviews the early studies in pediatric oncology showing the feasibility of this approach, describe the future plans to evaluate the clinical implications in a multi-center clinical trial and identify the challenges of applying genomics in this patient population. Published by Elsevier Inc.
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