期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 28, 页码 8206-8210出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201703187
关键词
carbonylation; cyclization; enantioselectivity; heterocycles; nickel
资金
- (JSPS KAKENHI) from MEXT [JP25708018, 2408, JP15H00943, JP15H05803]
- ACT-C from JST [JPMJCR12Y6]
- Frontier Research Base for Global Young Researchers, Osaka University, on the program of MEXT
- Spanish Ministerio de Economia y Competividad [CTQ2014-56361-P]
- Precisely Designed Catalysts with Customized Scaffolding (JSPS KAKENHI) from MEXT [JP16H01039]
- IRB Barcelona
- Grants-in-Aid for Scientific Research [16KT0057, 15H03780, 16H01039] Funding Source: KAKEN
The nickel(0)-catalyzed carbonylative cycloaddition of 1,5- and 1,6-ene-imines with carbon monoxide (CO) is reported. Key to this reaction is the efficient regeneration of the catalytically active nickel(0) species from nickel carbonyl complexes such as [Ni(CO)(3)L]. Avariety of tri-and tetracyclic gamma-lactams were thus prepared in excellent yields with 100% atom efficiency. Preliminary results on asymmetric derivatives promise potential in the synthesis of enantioenriched polycyclic gamma-lactams.
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