期刊
ADVANCED MATERIALS
卷 29, 期 26, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201605529
关键词
biointegrated devices; nanomedicine; nano-bio interfaces; programmable nanomaterials
类别
资金
- NTU-Northwestern Institute for Nanomedicine, Singapore
- Natural Science Foundation of China [21303145]
- Natural Science Foundation of Fujian Province of China [2014J01063]
A large amount of evidence has demonstrated the revolutionary role of nano-systems in the screening and shielding of biological systems. The explosive development of interfacing bioentities with programmable nanomaterials has conveyed the intriguing concept of nano-bio interfaces. Here, recent advances in functional biointegrated devices through the precise programming of nano-bio interactions are outlined, especially with regard to the rational assembly of constituent nanomaterials on multiple dimension scales (e.g., nanoparticles, nanowires, layered nanomaterials, and 3D-architectured nanomaterials), in order to leverage their respective intrinsic merits for different functions. Emerging nanotechnological strategies at nano-bio interfaces are also highlighted, such as multimodal diagnosis or theragnostics, synergistic and sequential therapeutics delivery, and stretchable and flexible nanoelectronic devices, and their implementation into a broad range of biointegrated devices (e.g., implantable, minimally invasive, and wearable devices). When utilized as functional modules of biointegrated devices, these programmable nano-bio interfaces will open up a new chapter for precision nanomedicine.
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