期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 64, 期 -, 页码 140-151出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2017.04.007
关键词
Sleep; Chronic sleep restriction; Alzheimer's disease; Amyloid-beta oligomers; Cytokines; TNF-alpha; IL-1 beta; IL-6; Hippocampus; Synaptic proteins; Synaptophysin; PSD-95; Inflammation
资金
- National Institute for Translational Neuroscience
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2014/50140-6]
It is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a bidirectional relationship. AD patients exhibit sleep problems and alterations in the regulation of circadian rhythms; conversely, poor quality of sleep increases the risk of development of AD. The aim of the current study was to determine whether chronic sleep restriction potentiates the brain impact of amyloid-beta oligomers (ABOs), toxins that build up in AD brains and are thought to underlie synapse damage and memory impairment. We further investigated whether alterations in levels of pro-inflammatory mediators could play a role in memory impairment in sleep-restricted mice. We found that a single intracerebroventricular (i.c.v.) infusion of A beta Os disturbed sleep pattern in mice. Conversely, chronically sleep-restricted mice exhibited higher brain expression of pro-inflammatory mediators, reductions in levels of pre- and post-synaptic marker proteins, and exhibited increased susceptibility to the impact of i.c.v. infusion of a sub-toxic dose of ABOs (1 pmol) on performance in the novel object recognition memory task. Sleep-restricted mice further exhibited an increase in brain TNF-alpha levels in response to A beta Os. Interestingly, memory impairment in sleep-restricted A beta O-infused mice was prevented by treatment with the TNF-alpha neutralizing monoclonal antibody, infliximab. Results substantiate the notion of a dual relationship between sleep and AD, whereby A beta Os disrupt sleep/wake patterns and chronic sleep restriction increases brain vulnerability to A beta Os, and point to a key role of brain inflammation in increased susceptibility to A beta Os in sleep-restricted mice. (C) 2017 Elsevier Inc. All rights reserved.
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