期刊
GENOME BIOLOGY
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13059-017-1261-8
关键词
-
资金
- French National Agency of Research (LabEx Saclay Plant Sciences-SPS) [ANR-10-LABX-0040-SPS]
- King Abdullah University of Science and Technology [CRG4]
- Czech Science Foundation GA CR [GA16-22044S]
Background: Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level. Results: Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase. Conclusions: By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据