期刊
ORIENTAL JOURNAL OF CHEMISTRY
卷 33, 期 2, 页码 628-636出版社
ORIENTAL SCIENTIFIC PUBL CO
DOI: 10.13005/ojc/330210
关键词
Chitosan; Norfloxacin; Film; Biomaterials; Wound dressing
资金
- Ministry of Higher Education [57080]
This research develops chitosan film incorporated norfloxacin (CH-NOR) designed to combat the infection of bacteria around the wound area. Inclusion of norfloxacin increased the strain-atbreak or flexibility of the film. Swelling behavior and water vapor transmission rates (WVTRs) values are improved and optimum for CH-NOR1.0 film at 524 +/- 65 % and 1916 +/- 78 g m(-2) d(-1), respectively. In-vitro cell studies show that the present of norfloxacin in CH film gradually decreased the number of human dermal fibroblast cell (CRL2522, ATCC) after incubated for 72 hours. In-contrast, antibacterial activities of CH-NOR films exhibit strong inhibition zones against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria.
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