期刊
CARBOHYDRATE POLYMERS
卷 168, 期 -, 页码 320-326出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.03.014
关键词
Drug delivery; Graphene oxide; Carboxymethyl cellulose; Nanocomposite; Hydrogel
资金
- University of Tabriz [938645702]
- Research Center for Pharmaceutical Nanotechnology (RCPN) of Tabriz University of Medical Science
Biodegradable carboxymethyl cellulose/graphene oxide (CMC/GO) nanocomposite hydrogel beads as a drug delivery system were prepared via physically crosslinking with FeCl3 center dot 6H(2)O for controlled release of anticancer drug doxorubicin (DOX). The pi-pi stacking interaction between DOX and GO resulted in higher loading capacity and controlled release of the DOX loaded from CMC/GO nanocomposites hydrogel. The release profile of DOX from hydrogel beads at pH 6.8 and 7.4 indicated it's strongly pH dependence. Interaction between GO and DOX with H-bonding could be unstable under acidic conditions which resulted in faster drug release rate in pH 6.8. The formation of GO nanoparticles in the hydrogels was confirmed using X-ray diffraction (XRD), and the chemical structure and morphology of the prepared CMC/GO nanocomposite hydrogel beads were characterized using Fourier transform infrared spectroscopy (FT-IR), SEM and Transmission electron microscopy (TEM). In addition, swelling behavior of nanocomposite hydrogels was investigated in PBS solution. (C) 2017 Elsevier Ltd. All rights reserved.
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