期刊
CORROSION SCIENCE
卷 123, 期 -, 页码 297-309出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.corsci.2017.04.016
关键词
Magnesium; Organic coatings; Polymer; Erosion; Interfaces; Kinetic parameters
资金
- National Natural Scientific Foundation of China [51571143, 51501115]
- Science and Technology Commission of Shanghai Municipality [14DZ1940800, 17XD1402100]
- National Key Research and Development Program of China [2016 YFC1102400]
To understand the possible influence of substrate degradation on the drug-loading system of magnesium alloy-based drug-eluting stents, a rapamycin drug-loading poly(lactic-co-glycolic acid) coating was prepared on Mg-d-Zn-Zr stents for a systematic investigation in a phosphate buffer system. Mg degradation accelerated the drug release kinetics prominently, which was mainly attributed to H-2 evolution in the diffusion-controlled phase while thereafter to PLGA erosion. Although physiochemical stability of the released rapamycin was partially deteriorated by magnesium degradation, the drug-loading system on magnesium substrates exhibited a more potent long-term inhibition on smooth muscle cell proliferation in vitro as compared to drug-loaded stainless steel.
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