期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 30, 页码 8642-8646出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201702347
关键词
B-H activation; boron; cage compounds; Grignard reagent; nucleophilic substitution
资金
- Research Grants Council of The Hong Kong Special Administration Region [14320616]
- NSFC/RGC [N_CUHK442/14]
- CUHK
Direct nucleophilic substitution reaction of cage B-H bonds of o-carboranes by Grignard reagents in the absence of any transition metals has been achieved for the first time, and leads to the regioselective synthesis of a series of 4-alkyl-1,2-diaryl-o-carboranes in very high yields. The presence of two electron-withdrawing aryl groups on the cage carbon atoms is crucial to realizing the reaction. The regioselectivity is controlled by both electronic and steric factors. This work represents a new strategy for the development of methods for carborane functionalization.
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