期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 38, 页码 9022-9025出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201701756
关键词
exo-N-acetyl-b-glucosaminidases; glycoclusters; glycosidases; iminosugars; multivalency
资金
- Centre National de la Recherche Scientifique (CNRS)
- Ministere de l'Enseignement Superieur et de la Recherche in France
- Grants-in-Aid for Scientific Research [17K08362] Funding Source: KAKEN
A set of multivalent polyhydroxylated acetamidoazepanes based on ethylene glycol, glucoside, or cyclodextrin scaffolds was prepared. The compounds were assessed against plant, mammalian, and therapeutically relevant hexosaminidases. Multimerization was shown to improve the inhibitory potency with synergy, and to fine tune the selectivity profile between related hexosaminidases.
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