期刊
CLINICS IN PLASTIC SURGERY
卷 44, 期 3, 页码 541-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cps.2017.02.013
关键词
Hypermetabolism; Hypercatabolism; Insulin resistance; Propranolol; Oxandrolone; Nutrition; Catecholamines
类别
Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.
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