期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 11, 页码 2817-2824出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2017.03.015
关键词
Guanidinium alkaloids; Marine natural products; Chemical probe; Structure-activity relationship; Mechanism of action
资金
- National Institutes of Health [R01GM117570]
- NC State University
The pentacyclic guanidinium alkaloids (PGAs) are a family of marine natural products that possess a poly cyclic guanidine-containing core and a long alkyl chain tethered spermidine-derived tail that is rarely observed in other natural products. These natural products exhibit potent activities on a wide range of organisms and therefore have attracted the attention of many synthetic chemists; however, the structure-activity relationships and mechanisms of action of PGAs remain largely elusive. Herein we summarize the structure, synthesis, toxicity and mechanisms of action of PGAs and highlight their potential as chemical probes and/or therapeutic leads. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据