期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 28, 页码 23325-23332出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b15387
关键词
MnO2 nanotubes; NanoSearchlight; multiple microRNAs; imaging live cells
资金
- WSU Start Up fund
- University at Buffalo Start Up fund
- China Scholarship Council (CSC)
- NIH Cancer Center Support [P30-CA01605]
- Translational Imaging Shared Resource at Roswell Park Cancer Institute
Sensitive assay and imaging of multiple low-abundance microRNAs (miRNAs) in living cells remain a grand challenge. Herein, based on polyelectrolyte-induced reduction, a facile approach has been proposed to synthesize novel MnO2 nanotubes. Owing to the remarkably strong fluorescence quenching ability, low cytotoxicity, and excellent colloid stability, the as-prepared MnO2 nanotubes showed great potential for simultaneous detection and Imaging of multiple miRNAs in vitro and in situ in living cells for the first time. Besides, MnO2 nanotubes can be reduced to Mn2+ by intracellular acid pH or glutathione, which may serve as an activatable contrast reagent for MRI. Therefore, the MnO2 nanotube-based probes, termed NanoSearchlight, provide a promising, multimodal imaging tool for precise and accurate diagnosis and prognosis of cancers.
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