期刊
GUT PATHOGENS
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13099-017-0160-6
关键词
beta-Lactoglobulin; Clostridium butyricum; Food allergy; Mice; Probiotics
资金
- innovation of science and Technology Commission of Shenzhen Municipality [JCYJ20120828092009036]
- National Natural Science Foundation [31371151]
Background: Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce beta-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy. Methods: The preventive and therapeutic effects of oral C. butyricum on anaphylactic symptoms induced via BLG in food allergy mice were investigated. Intestinal anaphylaxis, T helper (Th)-specific cytokines and transcription factors, secretory IgA (sIgA), CD4+CD25+Foxp3Treg cell and histopathological alterations were examined. Results: Clostridium butyricum significantly ameliorated intestinal anaphylaxis symptoms in the food allergy mice. sIgA and CD4+CD25+Foxp3Treg cell were increased by oral C. butyricum. It also reversed the imbalance of Th1/Th2 andTh17/Treg. Conclusions: Clostridium butyricum reduces BLG-induced intestinal anaphylaxis in mice and might be an additional or supplementary therapy for food allergy.
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