期刊
CHEMMEDCHEM
卷 12, 期 14, 页码 1116-1124出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201700218
关键词
bacteria; carbohydrates; gold nanoparticles; heterogeneity; shape
资金
- IISER Pune (India)
- Max-Planck partner group
- DST [SB/S1/C-46/2014]
- CSIR-SRF
- UGC-SRF
To investigate the effects of the heterogeneity and shape of glyco-nanoprobes on carbohydrate-protein interactions (CPIs), alpha-d-mannose-and beta-d-galactose-linked homo-and heterogeneous glycodendrons were synthesized and immobilized on spherical and rod-shaped gold nanoparticles (AuNPs). Lectin and bacterial binding studies of these glyco-AuNPs clearly illustrate that multivalency and shape of AuNPs contribute significantly to CPIs than the heterogeneity of glycodendrons. Finally, bacterial infection of HeLa cells was effectively inhibited by the homogeneous glycodendron-conjugated rod-shaped AuNPs relative to their heterogeneous counterparts. Overall, these results provide insight into the role of AuNP shape and multivalency as potential factors to regulate CPIs.
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