期刊
FOOD & FUNCTION
卷 8, 期 5, 页码 1810-1821出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7fo00341b
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资金
- China Agriculture Research System [CARS-24]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
A novel, homogeneous Pleurotus eryngii polysaccharide (PEP) (molecular weight 426 kDa, purity 91.25 +/- 3.14%) which mainly consisted of glucose with beta-type glycosidic linkages was used to investigate in vivo fermentation behavior and effects on immune response in mice. Different doses (0.2, 0.4, 0.8 g per kg body weight) were orally administered to the mice for a period of six weeks. The results showed that the SCFA concentration, pH value, and moisture contents of cecum and colon contents were significantly altered with high-dose PEP treatment compared to the control group (P < 0.05). Moreover, the fecal microbiota in the PEP treated group was found to be structurally different compared to the control group; especially, the Porphyromonadaceae, Rikenellaceae, Bacteroidaceae and Lactobacillaceae abundances were all increased at the family level. In addition, the exerted immune response was significantly altered after the high-dose PEP oral administration. This exploratory study indicated that intake of PEP could have a positive role in gastrointestinal tract health.
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