期刊
FOOD & FUNCTION
卷 8, 期 12, 页码 4657-4667出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7fo01429e
关键词
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资金
- State Key Research and Development Plan Modern food processing and food storage and transportation technology and equipment [2017YFD0400200]
- State Key Research and Development Program of China [2016YFD0400601]
- National Natural Science Foundation of China [31271810]
- Young Talent Fund of University Association for Science and Technology in Shaanxi, China [20170201]
- General Financial grant from the China Postdoctoral Science Foundation [2016 M602867]
Acrylamide (ACR) is a chronic neurotoxin that is generated in high-starch foods during heat processing. Alpha-lipoic acid (LA) is an antioxidant that occurs in most plants and animals. The objective of this study was to reveal the mechanism of ACR-triggered neurotoxicity and identify the protective role of LA in SH-SY5Y cells. In this study, LA restored ACR-stimulated depletion of glutathione content and mitochondrial membrane potential, moderated the activation of inflammatory pathways, and recovered the Keap1/Nrf2 pathway. Moreover, LA upregulated the activities of oxidative phosphorylation complexes and diminished ACR-induced variation in AMPK/GSK3 beta, Ca2+ disturbance, and ATP depletion. The Sirt1/PGC-1 alpha pathway was inhibited by ACR. Notably, autophagy was activated in the mitochondria-mediated apoptosis induced by ACR, which was also blocked by LA. Overall, our study demonstrated the pivotal roles of the mitochondrial energy metabolism and autophagy in the protective effects of LA and cytotoxicity of ACR in SH-SY5Y cells.
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