期刊
FOOD & FUNCTION
卷 8, 期 3, 页码 1282-1292出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7fo00147a
关键词
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资金
- National Natural Science Foundation of China [C31671823]
- Development program for Innovative Research Team of Shaanxi Normal University, China [GK201501006]
- Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province, China [2015KTCQ02-01]
- Construction Program of Chongqing Engineering Research Center [167001]
This study was designed to investigate the preventive effects of Red Fuji apple peel polyphenolic extract (APP) on vascular endothelial dysfunction and liver injury in mice fed a high choline diet. The mice were fed 3% dietary choline in drinking water for 8 weeks and displayed vascular dysfunction and liver damage (p < 0.01). The administration of APP at 600 and 900 mg per kg bw significantly elevated serum NO, HDL and 6-Keto-PGF1a levels and lowered serum TC, TG, LDL, ET-1 and TXB2 levels in the HC-fed mice. Besides, APP also caused the reduction of AST, ALT activities and MDA, CRP, TNF-alpha levels, and increased the hepatic GSH-Px and SOD activities of the HC-fed mice. Furthermore, the histopathology of the liver by conventional H&E and oil red O staining confirmed the liver steatosis induced by a choline diet and the hepatoprotective effect of APP. The experiment results indicated that the polyphenolic extract from apple peel might be regarded as a preventive and therapeutic product for the amelioration of HC diet-induced vascular dysfunction and hepatic injury.
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