期刊
FOOD & FUNCTION
卷 8, 期 3, 页码 1254-1270出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7fo00045f
关键词
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资金
- Consejeria de Economia, Innovacion y Ciencia of Junta de Andalucia [P06-FQM-01515]
- Grupo PAIDI of Junta de Andalucia [AGR-248, CTS-413]
- Universidad de Cordoba (Ayuda a Grupos)
- Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad (RETICEF)
- CIBER de Fragilidad y Envejecimiento Saludable, Spain
- Ministerio de Sanidad [FIS PI12/02315]
Extra virgin olive oil has positive effects on health. Oleuropein is a polyphenolic compound present in olive-tree leaves, fruits (olives) and olive oil. It is responsible for the relevant organoleptic and biological properties of olive oil, including antiadipogenic properties. Thus, the effects of oleuropein on the adipogenesis of human bone-marrow mesenchymal stem cells were studied by transcriptomics and differential gene-expression analyses. Oleuropein could upregulate expression of 60% of adipogenesis-repressed genes. Besides, it could activate signaling pathways such as Rho and beta-catenin, maintaining cells at an undifferentiated stage. Our data suggest that mitochondrial activity is reduced by oleuropein, mostly during adipogenic differentiation. These results shed light on oleuropein activity on cells, with potential application as a nutraceutical for the prevention and treatment of diseases such as obesity and osteoporosis.
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