期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 31, 页码 9217-9221出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705539
关键词
antibiotics; asymmetric catalysis; aza-pinacol rearrangement; indoline; phosphoric acid
资金
- 1000 Talents Recruitment Program
- Tsinghua-Peking University Center for Life Science
- National Natural Science Foudation of China [21302107, 21672123, 81671972, 31530082]
- Tsinghua University Research Program [20161080058]
- Grand Challenges Exploration of the Bill and Melinda Gates Foundation [OPP1021992]
The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state involving a cyclic aza-ortho-xylylene intermediate to afford the indoline structures with good to excellent enantioselectivity. The synthetic utility of this method is demonstrated by the asymmetric synthesis of a key intermediate to the natural product minfiensine and the identification of a chiral lead compound to repress antibiotic resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据