期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 31, 页码 9029-9033出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201703159
关键词
cancer therapy; free radicals; gold nanocages; photothermal processes
资金
- National Natural Science Foundation of China [51233003, 51690152]
Tumor hypoxia greatly suppresses the therapeutic efficacy of photodynamic therapy (PDT), mainly because the generation of toxic reactive oxygen species (ROS) in PDT is highly oxygen-dependent. In contrast to ROS, the generation of oxygen-irrelevant free radicals is oxygen-independent. A new therapeutic strategy based on the light-induced generation of free radicals for cancer therapy is reported. Initiator-loaded gold nanocages (AuNCs) as the free-radical generator were synthesized. Under near-infrared light (NIR) irradiation, the plasmonic heating effect of AuNCs can induce the decomposition of the initiator to generate alkyl radicals (RC), which can elevate oxidative-stress (OS) and cause DNA damages in cancer cells, and finally lead to apoptotic cell death under different oxygen tensions. As a proof of concept, this research opens up a new field to use various free radicals for cancer therapy.
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