4.7 Review

The new era of nanotechnology, an alternative to change cancer treatment

期刊

DRUG DESIGN DEVELOPMENT AND THERAPY
卷 11, 期 -, 页码 2871-2890

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S142337

关键词

nanotechnology; gold nanoparticles; liposomes; dendrimers; microRNA; RNA interference

资金

  1. POC grant
  2. South Africa [7 BM/2016]
  3. Iuliu Hatieganu University of Medicine and Pharmacy (UMF), Cluj-Napoca [5200/52/15.04.2016]
  4. Romanian Research Ministry [PN-II-RU-TE-2014-4-1783, CNFIS-FDI-2017-1350]
  5. Romania and People's Republic of China [57 BM/2016]

向作者/读者索取更多资源

In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies. A particular key point is the functional characterization of nonviral delivery systems, such as gold nanoparticles, liposomes and dendrimers. The paper also presents relevant published data related to microRNA and RNA interference delivery using nanoparticles in cancer therapy.

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