期刊
DRUG DESIGN DEVELOPMENT AND THERAPY
卷 11, 期 -, 页码 2871-2890出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S142337
关键词
nanotechnology; gold nanoparticles; liposomes; dendrimers; microRNA; RNA interference
资金
- POC grant
- South Africa [7 BM/2016]
- Iuliu Hatieganu University of Medicine and Pharmacy (UMF), Cluj-Napoca [5200/52/15.04.2016]
- Romanian Research Ministry [PN-II-RU-TE-2014-4-1783, CNFIS-FDI-2017-1350]
- Romania and People's Republic of China [57 BM/2016]
In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies. A particular key point is the functional characterization of nonviral delivery systems, such as gold nanoparticles, liposomes and dendrimers. The paper also presents relevant published data related to microRNA and RNA interference delivery using nanoparticles in cancer therapy.
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