期刊
DIABETOLOGY & METABOLIC SYNDROME
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13098-017-0283-4
关键词
Steel workers; Shift work; Metabolic syndrome; Body mass index; Fasting glucose; Triglyceride; Highdensity lipoprotein-cholesterol; Resistin; White blood cell count
资金
- E-Da Hospital of the Republic of China, Taiwan [EDAHP105061, EDAHP105038]
Aims: There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male steel workers, and also the possible mechanism of shift work-related metabolic derangements. Methods: A total of 1732 men aged 42 +/- 8 years were enrolled in this cross-sectional study, including 862 day workers and 870 shift workers. Circulating levels of resistin were measured by ELISA using monoclonal specific antibodies. Results: The shift workers had higher rates of MetS and its components (central obesity, hypertension, and hypertriglyceridemia) than the day workers. In multiple logistic regression analysis, shift work was independently associated with MetS. In further analysis, the shift workers had elevated circulating levels of resistin (13 +/- 10 vs. 10 +/- 7 ng/mL) and total white blood cell (WBC) count (6.865 +/- 1.819 vs. 6.304 +/- 1.547 10(9)/L) than the day workers. In addition, both resistin level and total WBC count were significantly associated with shift work, MetS, and its components (body mass index, fasting glucose, triglyceride, and high-density lipoprotein-cholesterol levels), and plasma resistin levels were significantly associated with total WBC count (beta = 0.34, p < 0.0001). Conclusion: Shift work was independently associated with MetS in male steel workers. Resistin and WBC count were associated with shift work-related metabolic derangements.
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