期刊
WORLD JOURNAL OF DIABETES
卷 8, 期 7, 页码 337-345出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4239/wjd.v8.i7.337
关键词
Adipokines; Adipose tissue; Insulin resistance; Antidiabetic; Obesity
Development of type 2 diabetes has been linked to beta-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we summarized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.
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