期刊
CURRENT PSYCHIATRY REPORTS
卷 19, 期 10, 页码 -出版社
SPRINGER
DOI: 10.1007/s11920-017-0829-z
关键词
PTSD; Synapse; Glutamate; NMDA; Ketamine; Plasticity; Connectivity
类别
资金
- US Department of Veterans Affairs
- US Department of Defense, of the Consortium to Alleviate PTSD
- National Center for Advancing Translational Science [UL1RR024139]
- US National Institute on Alcohol Abuse and Alcoholism [P50AA12870]
- State of Connecticut for the Abraham Ribicoff Research Facilities of the Connecticut Mental Health Center
- Society of Biological Psychiatry
Purpose of Review Studies of the neurobiology and treatment of PTSD have highlighted many aspects of the pathophysiology of this disorder that might be relevant to treatment. The purpose of this review is to highlight the potential clinical importance of an often-neglected consequence of stress models in animals that may be relevant to PTSD: the stress-related loss of synaptic connectivity. Recent Findings Here, we will briefly review evidence that PTSD might be a synaptic disconnection syndrome and highlight the importance of this perspective for the emerging therapeutic application of ketamine as a potential rapid-acting treatment for this disorder that may work, in part, by restoring synaptic connectivity. Summary Synaptic disconnection may contribute to the profile of PTSD symptoms that may be targeted by novel pharmacotherapeutics.
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