期刊
CURRENT PSYCHIATRY REPORTS
卷 19, 期 11, 页码 -出版社
SPRINGER
DOI: 10.1007/s11920-017-0840-4
关键词
Posttraumatic stress disorder; Default mode network; Central executive network; Salience network; Functional magnetic resonance imaging; Structural MRI
类别
资金
- US Department of Veterans Affairs (DVA) National Center for PTSD, NIH [MH-101498]
- Brain and Behavior Foundation Young Investigator Award [NARSAD]
Purpose of Review Although a fine-grained understanding of the neurobiology of posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen a rapid growth in the study of PTSD using neuroimaging techniques. The current review summarizes important findings from functional and structural neuroimaging studies of PTSD, by primarily focusing on their relevance towards an emerging network-based neurobiological model of the disorder. Recent Findings PTSD may be characterized by a weakly connected and hypoactive default mode network (DMN) and central executive network (CEN) that are putatively destabilized by an overactive and hyperconnected salience network (SN), which appears to have a low threshold for perceived saliency, and inefficient DMN-CEN modulation. Summary There is considerable evidence for large-scale functional and structural network dysfunction in PTSD. Nevertheless, several limitations and gaps in the literature need to be addressed in future research.
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