期刊
CURRENT HYPERTENSION REPORTS
卷 19, 期 7, 页码 -出版社
SPRINGER
DOI: 10.1007/s11906-017-0750-1
关键词
Hypertension; Obesity; Insulin; Leptin; Central nervous system; Sympathetic nervous system; Hypothalamus; High fat diet; Aversive stress; Blood pressure
资金
- National Health & Medical Research Council of Australia (NHMRC) [APP526618, APP1043205]
- Victorian Government's Operational Infrastructure Support Program
- NHMRC Fellowship [APP1002186, APP1091688]
- NHMRC Postdoctoral Fellowship [APP1053928]
- Heart Foundation Fellowship
- Japan Heart Foundation/Bayer Yakuhin Research Grant Abroad
- JSPS KAKENHI [JP 25.5473]
Purpose of Review The major health issue of being overweight or obese relates to the development of hypertension, insulin resistance and diabetic complications. One of the major underlying factors influencing the elevated blood pressure in obesity is increased activity of the sympathetic nerves to particular organs such as the kidney. Recent Findings There is now convincing evidence from animal studies that major signals such as leptin and insulin have a sympathoexcitatory action in the hypothalamus to cause hypertension. Recent studies suggest that this may involve 'neural plasticity' within hypothalamic signalling driven by central actions of leptin mediated via activation of melanocortin receptor signalling and activation of brain neurotrophic factors. Summary This review describes the evidence to support the contribution of the SNS to obesity related hypertension and the major metabolic and adipokine signals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据