期刊
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
卷 25, 期 6, 页码 595-604出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jagp.2017.01.005
关键词
Dementia; Lewy; visual; superior colliculus; neuropathology; neuropsychiatry
资金
- U.K. Medical Research Council [G0400074]
- NIHR Newcastle Biomedical Research Centre and Unit
- Newcastle University
- Alzheimer's Research U.K.
- Alzheimer's Society
- NHS National Institute of Health Research Biomedical Research Unit for Lewy body dementia at Newcastle upon Tyne Hospitals NHS Foundation Trust
- MRC [G0502157, G0900652, G0400074, G1100540] Funding Source: UKRI
- Alzheimer's Society [181] Funding Source: researchfish
- Medical Research Council [G0502157, G0400074, G1100540, G0900652] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10048] Funding Source: researchfish
Objective: Patients with dementia with Lewy bodies (DLB) often experience visual hallucinations, which are related to decreased quality of life for patients and increased caregiver distress. The pathologic changes that contribute to visual hallucinations are not known, but several hypotheses implicate deficient attentional processing. The superior colliculus has a role in visual attention and planning eye movements and has been directly implicated in several models of visual hallucinations. Therefore, the present study sought to identify neurodegenerative changes that may contribute to hallucinations in DLB. Methods: Postmortem superior colliculus tissue from 13 comparison, 10 DLB, and 10 Alzheimer disease (AD) cases was evaluated using quantitative neuropathologic methods. Results: alpha-Synuclein and tau deposition were more severe in deeper layers of the superior colliculus. DLB cases had neuronal density reductions in the stratum griseum intermedium, an important structure in directing attention toward visual targets. In contrast, neuronal density was reduced in all laminae of the superior colliculus in AD. Conclusion: These findings suggest that regions involved in directing attention toward visual targets are subject to neurodegenerative changes in DLB. Considering several hypotheses of visual hallucinations implicating dysfunctional attention toward external stimuli, these findings may provide evidence of pathologic changes that contribute to the manifestation of visual hallucinations in DLB.
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