期刊
BMC BIOLOGY
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12915-017-0399-x
关键词
Parasteatoda tepidariorum; Genome; Centruroides sculpturatus; Gene duplication; Evolution; Hox genes
类别
资金
- NIH [NHGRI U54 HG003273]
- National Science Foundation, Leverhulme visiting fellowship for EES [IOS-0951886, DEB-1257053, VF-2012-016]
- Oxford Brookes University
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Deutsche Forschungsgemeinschaft [PR 1109/4-1, PR 1109/7-1, PR 1109/6-1]
- Gottingen Graduate School for Neurosciences, Biophysics and Molecular Biosciences (GGNB)
- Gottingen Center for Molecular Biosciences (GZMB)
- University of Gottingen (GAU)
- Christiane-Nusslein- Volhard-Foundation fellowship
- L'Oreal Deutschland
- Deutsche UNESCO-Kommission
- Volkswagen Foundation [85983]
- Emmy Noether Programme of Deutsche Forschungsgemeinschaft [PO 1648/3-1]
- Swedish Research Council VR [621-2011-4703]
- Grants-in-Aid for Scientific Research [17K07418, 15K07139, 26440130] Funding Source: KAKEN
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1552610] Funding Source: National Science Foundation
Background: The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. Results: We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. Conclusions: Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.
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