期刊
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
卷 29, 期 9, 页码 1107-1111出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/09540121.2017.1281880
关键词
Stress; worry; anxiety; depression; T cells
类别
资金
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Cancer Institute (NCI)
- National Institute on Drug Abuse (NIDA)
- National Institute on Mental Health (NIMH)
- National Institute of Dental and Craniofacial Research (NIDCR)
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- National Institute on Deafness and other Communication Disorders (NIDCD)
- NIH Office of Research on Women's Health
Psychological stress is a known immunomodulator. In individuals with HIV, depression, the most common manifestation of increased psychological stress, can affect immune function with lower CD4+ T cell counts correlating with higher levels of depression. It is unknown how other forms of psychological stress can impact immune markers in people living with HIV. We conducted a cross-sectional study to determine how CD4+ T cell subpopulations correlated with different forms of psychological stress. We recruited 50 HIV-positive women as part of the Women's Interagency HIV Study. We assessed perceived stress, worry, acute anxiety, trait anxiety, and depression through self-report questionnaires and CD4+ T cell subpopulations using flow cytometry. Our sample was 96% African-American with a mean +/- SD age and body mass index of 42 +/- 8.8 years and 36.6 +/- 11.5kg/m(2), respectively. The mean +/- SD scores on the psychological measures were as follows: Perceived Stress Scale (PSS), 16.5 +/- 6.4; Penn State Worry Questionnaire (PSWQ), 47.7 +/- 13.8; State-Trait Anxiety Inventory - State (STAIS), 39.1 +/- 12.3; State-Trait Anxiety Inventory - Trait (STAIT), 40.2 +/- 11.4; Center for Epidemiological Studies Depression Scale (CES-D), 15.6 +/- 11.4. The mean+SD values for the immune parameters were as follows: regulatory T cells (Treg), 1.25%+/- 0.7; T helper 1 (Th1), 14.9%+/- 6.1; T helper 2 (Th2), 3.8%+/- 2; Th1/Th2 ratio, 4.6 +/- 3; and CD4+ T cell count (cells/mm(3)), 493 +/- 251. Treg levels positively correlated with PSS, STAIS, and STAIT. CD4+ T cell count negatively correlated with PSS, PSWQ, STAIS, STAIT, and CES-D. These data suggest that immune function may be impacted by various forms of psychological stress in HIV-positive women. Interventions that target stress reduction may be useful in improving immune parameters and quality of life.
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