期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 39, 期 -, 页码 133-142出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.06.014
关键词
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资金
- National Institutes of Health [R01CA178394]
- American Heart Association
- Sidney Kimmel Foundation for Cancer Research
- Gabrielle's Angels Foundation for Cancer Research
- Alexandrine and Alexander L. Sinsheimer Foundation
- Pershing Square Sohn Cancer Research Alliance
- Melanoma Research Alliance
- Irma T. Hirschl Trust
The network of protein-protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondria! apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting BCL-2 family interactions. These studies advance our understanding of the role of BCL-2 family proteins in physiology and disease, providing unique tools for dissecting these functions. The BCL-2 family of proteins is a prime example of targeting protein-protein interactions and further chemical biology approaches will increase opportunities for novel targeted therapies in cancer, autoimmune and aging-associated diseases.
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