期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 30, 期 12, 页码 1299-1315出版社
SPRINGER
DOI: 10.1007/s10654-015-0105-7
关键词
Epidemiology; Population-based; Risk factors; Neuroimaging; Cohort study; Dementia; Stroke; Alzheimer's disease; Microbleeds; White matter lesions; Infarcts; Cerebral blood flow; Diffusion tensor imaging; Genetics
资金
- Erasmus MC University Medical Center
- Erasmus University Rotterdam
- Netherlands Organization for Scientific Research (NWO) [918-46-615]
- Netherlands Organization for Health Research and Development (ZonMW)
- Research Institute for Disease in the Elderly (RIDE)
- European Union [601055]
- VPH-DARE@IT
- Dutch Technology Foundation STW
- Netherlands Organisation for Health Research and Development (ZonMW Veni Grant) [916.13.054]
- Netherlands Heart Foundation [2009B102, 2012T008]
- New Investigator Research Grant from the Alzheimer Association [2014-NIRG-305710]
- MRace grant Erasmus MC
- Erasmus MC Fellowship
- Biobanking and Biomolecular Research Infrastructure (BBMRI) [CP2013-67]
- Internationale Stichting Alzheimer Onderzoek Grant [12533]
- Stichting Parkinson-Fonds
- ZonMW [90700453]
- Alzheimer Nederland [WE03.2012-030]
- Alzheimers Association [NIRG-08-91391]
- General Electric Health Care
Imaging plays an essential role in research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to elucidate the causes of neurological disease by performing imaging of the brain in a prospective population-based setting. Initially, in 1995 and 1999, random subsamples of participants from the Rotterdam Study underwent neuroimaging, whereas from 2005 onwards MRI has been implemented into the core protocol of the Rotterdam Study. In this paper, we discuss the background and rationale of the Rotterdam Scan Study. Moreover, we describe the imaging protocol, image post-processing techniques, and the main findings to date. Finally, we provide recommendations for future research, which will also be topics of investigation in the Rotterdam Scan Study.
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