期刊
CANCER GENETICS
卷 216, 期 -, 页码 105-110出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergen.2017.06.003
关键词
Long noncoding RNA; biological function; regulatory mechanism; gene expression; tumorigenesis
资金
- Zhejiang Provincial Natural Science Foundation of China [LY14C060003]
- Applied Research Project on Nonprofit Technology of Zhejiang Province [2016033177]
- National Natural Science Foundation of China [81171660]
- Scientific Innovation Team Project of Ningbo [20170110019]
- Ningbo University
Long non-coding RNAs (IncRNAs) are a heterogeneous class of RNAs that are non-protein coding transcripts longer than 200 nucleotides. In this review, we introduce the mechanisms by which IncRNAs regulate gene expression in four parts, epigenetic regulation (genetic imprinting and chromatin remodeling), transcriptional regulation (molecular decoy), post-transcriptional regulation (splicing and mRNA decay), and translational regulation. H19, Xist, and others are involved in genomic imprinting. HOTAIR and ANRIL function in chromatin remodeling. GAS5 is degraded through an RNA decay pathway. NEAT1 and MALAT1 function not only in the regulation of transcription but also in splicing.
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