期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 27, 期 15, 页码 3374-3377出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.06.011
关键词
Caffeic acid; Melanogenesis; alpha-MSH; Caffeamide; Skin whitening
资金
- National Research Foundation of Korea grant - Korea Government (MSIP) [MRC, 2008-0062275]
- International Science and Business Belt Program through the Ministry of Science, ICT and Future Planning [2016K000297]
- Chungbuk National University
We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of alpha-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities. (C) 2017 Elsevier Ltd. All rights reserved.
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