期刊
DATA IN BRIEF
卷 13, 期 -, 页码 620-640出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dib.2017.06.031
关键词
Antibody; Gene inference; Germline repertoire; Immunoglobulin germline gene; Transcriptome; Validation
资金
- Swedish Research Council
- Uppsala Multidisciplinary Center for Advanced Computational Science
Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germ line gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcriptome data sets. Specifically, the data has been used to validate (Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery (DOI: 10.1016/j.molimm.2017.03.012) (Kirik et al., 2017) [1]) the inference process. This was accomplished based on analysis of the inferred germline genes' association to the donors' different haplotypes as defined by their different, expressed IGHJ alleles and/or IGHD genes/alleles. The data is important for development of validated germline gene databases containing entries inferred from immunoglobulin-encoding transcriptome sequencing data sets, and for generation of valid, personalized antibody germline gene repertoires. (C) 2017 The Authors. Published by Elsevier Inc.
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